Structural bases for blockade and activation of BK channels by Ba2+ ions
Year: 2024
Type: article
Abstract: Ba 2+ increases open probability and blocks the permeation pathway of BK channels. Here we discuss Cryo-EM structures of BK channels with Ba 2+ . They reveal that Ba 2+ occupies site S3 in the selectivity filter, leading to blockade. Ba 2+ are also detected at all high affinity Ca 2+ binding sites of the gating ring. However, the architectures of this region in these structures represent intermediate transitions between the extreme close and open configurations.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,295
Funder: National Institutes of Health
OpenAlex ID: W4402604836