Work

Lysine methylation steps into another step of the central dogma

Year: 2024

Type: article

Abstract: Lysine methylation is an important protein modification that regulates replication and transcription, the fundamental events of the central dogma. However, whether it plays a role in translation, the last step of the central dogma, remains unclear. Two recent studies revealed that lysine methyltransferase SMYD5 catalyzes the trimethylation of lysine 22 in ribosomal protein RPL40, enhances translation output, and promotes cancer progression .

Source: Cell Research

DOI: 10.1038/s41422-024-01033-z

Authors: Zuodong Zhao, Bing Zhu

Institutions: Chinese Academy of Sciences, Institute of Biophysics, University of Chinese Academy of Sciences

Language: English

Topic: Cancer-related gene regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,990

OpenAlex ID: W4402606204