Transition Metal–Free Synthesis of Vinyl Nitriles from Aldehydes with Acetonitrile at Room Temperature
Year: 2024
Type: article
Abstract: A simple and mild protocol for the direct synthesis of vinyl nitriles is described. By employing potassium trimethylsilanolate as the mild base and benzyl chloride as the efficient promoter, a series of E‐configured vinyl nitriles are selectively obtained from readily available aldehydes and acetonitrile at room temperature without the aid of a transition metal catalyst. Mechanistical investigations reveal that this transformation may go through a Knoevenagel condensation process.
Source: ChemistrySelect
Authors: Qing Li, Wenjing Liu, Yuyao Xie, Feng Zhao
Institution: Hunan University of Medicine
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4402622232