Work

Unveiling the macrophage dynamics in osteoarthritic joints: From inflammation to therapeutic strategies

Year: 2024

Type: article

Abstract: Osteoarthritis (OA) is an incurable, painful, and debilitating joint disease affecting over 500 million people worldwide. The OA joint tissues are infiltrated by various immune cells, particularly macrophages, which are able to induce or perpetuate inflammation. Notably, synovitis and its macrophage component represent a target of interest for developing treatments. In this review, we describe the latest advances in understanding the heterogeneity of macrophage origins, phenotypes, and functions in the OA joint and the effect of current symptomatic therapies on these cells. We then highlight the therapeutic potential of anticytokines/chemokines, nano- and microdrug delivery, and future strategies to modulate macrophage functions in OA.

Source: Drug Discovery Today

DOI: 10.1016/j.drudis.2024.104187

Authors: Nicolas Gaigeard, Anaïs Cardon, Benoit Le Goff, Jérôme Guicheux, Marie-Astrid Boutet