Phagocyte dynamics in the blastogenetic cycle of the colonial ascidian Botryllus schlosseri: Cell senescence, segregation and clearance after efferocytosis
Year: 2024
Type: article
Abstract: In the colonial ascidian Botryllus schlosseri , phagocytes are involved in the clearance of apoptotic cells and corpses during the periodical generation changes or takeovers (TOs) that assure the renewal of the colonial zooids. The persistent respiratory burst associated with efferocytosis, leads to the induction of senescence. Indeed, giant, senescent phagocytes are abundant in the colonial circulation at TO, whereas, in the other phases of the colonial blastogenetic cycle, they colonise the ventral islands (VIs), a series of mesenchymal niches located in the lateral lacunae of the mantle, on both sides of the subendostylar sinus. VI phagocytes produce reactive oxygen species probably as a consequence of the massive phagocytosis of effete cells. VIs are progressively dismantled with the progress of the blastogenetic phases and phagocytes are released in the peribranchial chamber via transepithelial expulsion to be definitely expelled with the outflowing water through the cloacal siphon. • Botryllus phagocytes undergo senescence after the ingestion of apoptotic cells. • Senescent phagocytes colonise the ventral islands of the new zooid generation. • Ventral islands reach their maximum size at mid-cycle and are dismantled at takeover. • Senescent phagocytes accumulate lipofuscin and ceroids in their cytoplasm. • Phagocytes are finally expelled from the ventral islands into the outflowing water.
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,480
Awards: G3736083458, G7719614766, G952189410
OpenAlex ID: W4402630924