Year: 2024
Type: review
Abstract: Hyperkatifeia, the manifestation of emotional distress or pain, is a conceptual framework gaining traction throughout the alcohol and other substance use fields as an important driver of addiction. It is well known that previous or current negative life experiences can serve as powerful motivators for excessive alcohol consumption and precipitate the development of an alcohol use disorder (AUD). A major hallmark of later stages of AUD is the emergence of hyperkatifeia during withdrawal, which can persist well into protracted abstinence to drive relapse. Given these complex interactions, understanding the specific neuroadaptations that lie at the intersection of hyperkatifeia and AUD can inform ongoing therapeutic development. The monoamine norepinephrine is of particular interest. Noradrenergic dysfunction is implicated in AUD, anxiety, chronic stress, depression, and emotional and physical pain. Importantly, there are key sexual dimorphisms within the noradrenergic system that are thought to differentially impact the development and trajectory of AUD in women and men. In the current review, we discuss past and recent work on noradrenergic influences at each stage of the AUD cycle (binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation) through the lens of hyperkatifeia. Evidence from these studies support the prioritization of norepinephrine-specific drug development to treat AUD and the identification of AUD subpopulations that may benefit the most from these therapies (e.g., women or people with comorbid chronic pain or anxiety/stress disorders).
Source: Biological Psychiatry
Institutions: Binghamton University, Scripps Research Institute
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,990
Awards: G170229325, G1902745206, G194875419, Neuroplasticity of the Extended Amygdala CRF circuitry in alcohol dependence, Alcohol-induced neuroadapation of prefrontal cortical projections, Neuroimmune mechanisms in stress and alcohol comorbidity, Neuroimmune mechanisms of adult chronic ethanol consumption, Alcohol-induced neuroadapation of prefrontal cortical projections, Gene-environment interaction: the brain CRF system in alcohol preferring msP rats, 9/10 Electrophysiology of Alcohol in Extended Amygdala, Synaptic Mechanisms underlying sex-differences in alcohol use disorder, NEUROPSYCHOPHARMACOLOGY: MULTIDISCIPLINARY TRAINING, Gene-environment interaction: the brain CRF system in alcohol preferring msP rats, Developmental Exposure Alcohol Research Center, CNS Effects of Alcohol: Cellular Neurobiology
OpenAlex ID: W4402632748