Work

Lower or Higher Oxygenation Targets in Patients With COVID-19 in the ICU

Year: 2024

Type: article

Abstract: BACKGROUND: target of 60 mm Hg compared with 90 mm Hg resulted in more days alive without life support at 90 days in adults in the ICU with COVID-19 and hypoxemia. The trial was stopped after enrolling 726 of 780 planned patients because of slow recruitment. Herein, we present the preplanned Bayesian analysis of the HOT-COVID trial. RESEARCH QUESTION: target of 60 mm Hg vs 90 mm Hg in adult patients with COVID-19 and hypoxemia in the ICU and does heterogeneity of treatment effects (HTE) exist according to selected baseline characteristics? STUDY DESIGN AND METHODS: ratio, norepinephrine doses, and lactate concentrations. RESULTS: target. The risk difference in 90-day mortality was -4.6 percentage points (95% credible interval, -11.8 to 2.6 percentage points), with a 76.5% probability of a clinically relevant benefit from the lower target. HTE analyses revealed potential interaction with baseline norepinephrine dose and lactate concentrations for both outcomes. INTERPRETATION: of 60 mm Hg vs 90 mm Hg on number of days alive without life support. CLINICAL TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT04425031; URL: www. CLINICALTRIALS: gov.

Source: CHEST Journal

DOI: 10.1016/j.chest.2024.08.055