Agonist-antagonist myoneural interface surgery on the proprioceptive reconstruction of rat hind limb
Year: 2024
Type: article
Abstract: Currently, prosthesis users rely on visual cues to control their prosthesis. One reason for this is that prostheses cannot provide users with proprioceptive functional signals. For this reason, we propose an agonist-antagonist myoneural interface (AMI) surgery. We examined how this surgery affects the restoration of motor function and proprioceptive reconstruction in the hind limb of Sprague-Dawley rats. The procedure entails grafting the soleus muscle, suturing the two tendon ends of the soleus muscle, and anastomosing the tibial and common peroneal nerves to the soleus muscle. We found that, following surgery, AMI rats exhibited improved neurological repair, shorter walking swings, braking, propulsion, and stance times, and greater compound action potentials than control rats. This means that in rats with neurological impairment of the hind limb, the proposed AMI surgical method significantly improves postoperative walking stability and muscle synergy. AMI surgery may become an option for regaining proprioception in the lost limb.
Source: Heliyon
Authors: Ping Wang, Jianping Huang, Jingjing Wei, Qianhengyuan Yu, Guanglin Li, Bin Yu, Lin Yang, Zhiyuan Liu
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,100
Funders: Shandong University, Innovative Research Group Project of the National Natural Science Foundation of China, National Natural Science Foundation of China, Chinese Academy of Sciences, National Key Scientific Instrument and Equipment Development Projects of China, Key Technologies Research and Development Program
OpenAlex ID: W4402654047