Work

Efficient Synthesis of the Pyoverdine Chromophore: Expanding the Toolbox for the Preparation of Pyoverdine Conjugates

Year: 2024

Type: article

Abstract: The pyoverdine chromophore is an important component of a family of siderophores which are secreted by the human pathogen Pseudomonas aeruginosa for iron absorption. In this study, an efficient and improved synthetic route to the chromophore structure is reported, beginning from readily available starting materials, D‐glutamic acid and L–DOPA. This strategy has not only delivered the first synthesis of the free pyoverdine D chromophore, but also offers potential access to a wide range of other pyoverdine chromophore species.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202400745

Authors: Tianzhu Zhang, Albert Bolhuis, Ian M. Eggleston

Institution: University of Bath

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $4,330

Funder: University of Bath