Work

Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying bla NDM-5 and bla KPC-3 from foreign fighters evacuated from Ukraine

Year: 2024

Type: article

Abstract: ABSTRACT Genomic surveillance detected clonal Escherichia coli sequence type-361 isolates carrying bla NDM-5 , bla KPC-3 , bla CTX-M-15 , and rmtB1 from a patient in Ukraine and four wounded foreign soldiers evacuated to Germany. Isolates were non-susceptible to carbapenems, aminoglycosides, and cefiderocol and aztreonam/avibactam due to a PBP3 YRIN insertion and the bla CMY-145 AmpC β-lactamase. Coordinated surveillance efforts across civilian, military, and veteran healthcare systems are essential to prevent further spread as international volunteers return home after medical evacuation from Ukraine.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01090-24

Authors: Melissa J. Martin, Ting L. Luo, Valentyn Kovalchuk, Viacheslav Kondratiuk, Henry D. Dao, Iryna Kovalenko, Brandon J. Plaza, Joanna M. Kettlewell, Cole P. Anderson, Jason R. Smedberg, Ana C. Ong, Yoon I. Kwak, Joshua S. Hawley-Molloy, Jason W. Bennett, Patrick T. McGann, Francois Lebreton

Institutions: Walter Reed Army Institute of Research, National Pirogov Memorial Medical University, Vinnytsya, Landstuhl Regional Medical Center

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4402665005

FWCI: 1.907

Cites: 13

Cited by: 18

Related to: 10