Work

Discovery of KW0113 as a First and Effective PROTAC Degrader of DNMT1 Protein

Year: 2024

Type: article

Source: ChemMedChem

DOI: 10.1002/cmdc.202400467

Authors: Huihui Wang, Zhaoliang Wang, Linghao Hu, Bingjie Yang, Liangyi Zong, Dounan Xu, Bo Yu, Xiangqian Kong, Mingliang Wang

Institutions: Nanchang University, Chinese Academy of Sciences, Shanghai Institute of Materia Medica, Guangzhou Institutes of Biomedicine and Health, State Key Laboratory of Respiratory Disease, University of Chinese Academy of Sciences

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation, Basic and Applied Basic Research Foundation of Guangdong Province

Awards: G4559027212, G4636995232, G7226403530

OpenAlex ID: W4402665545

FWCI: 0.822

Cites: 49

Cited by: 7

Related to: 10