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Family History of Diabetes and Clinical Characteristics in Children at Diagnosis of Type 1 Diabetes—A Swedish Population-Based Study

Year: 2024
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To compare the prevalence of parental diabetes between children with and without type 1 diabetes (T1D), and to compare clinical characteristics at diagnosis of T1D in children with, versus without, a family history of diabetes. RESEARCH DESIGN AND METHODS: Parental diabetes among children with T1D was compared with a general population cohort. Clinical characteristics were compared by family history of diabetes in parents and grandparents of 3,603 children with T1D using relative risk (RR) and ANOVA. RESULTS: Children with T1D more often had parents with type 2 diabetes (T2D) (RR 1.88; P < 0.001) than did children without diabetes. Children with T1D and a family history of T2D were more likely to be overweight or obese (P = 0.002). CONCLUSIONS: A family history of T2D and being overweight may contribute to increased risk of T1D.
DOI: 10.2337/dc24-0534
Authors: Emma Hedlund, Jasaman Tojjar, Lisa Lilja, Helena Elding Larsson, Gun Forsander, Johnny Ludvigsson, Claude Marcus, Fredrik Norström, Martina Persson, Annelie Carlsson
Institutions: Lund University, Centralsjukhuset Kristianstad, University of California, Los Angeles, Skåne University Hospital, Sahlgrenska University Hospital, University of Gothenburg, Linköping University, Linköping University Hospital, Karolinska Institutet, Umeå University, Stockholm South General Hospital, Sachs' Children and Youth Hospital
Language: English
Subfield: Genetics
Open Access status: bronze
Awards: G1513236869, G1558193350, G2004031785, G2563633029, G263730981, G3918735012, G583733011, G67379338, LUDC-IRC för individanpassad medicin i diabetes
OpenAlex ID: W4402675475
FWCI: 1.962
Cites: 20
Cited by: 8
Related to: 10