Work

TLR2 promotes traumatic deep venous thrombosis of the lower extremity following femoral fracture by activating the NF‑κB/COX‑2 signaling pathway in rats

Year: 2024

Type: article

Abstract: experiments showed that Pam3CSK4 treatment resulted in a higher number of apoptotic cells than C29 treatment and that it increased the levels of NF-κB, COX-2, IL-6 and P-selectin, whereas C29 decreased them. Thus, TLR2 promotes the inflammatory response in EC through the NF-κB/COX-2 signaling pathway, which may lead to EC apoptosis and the occurrence of TDVT.

Source: Experimental and Therapeutic Medicine

DOI: 10.3892/etm.2024.12725

Authors: Tianting Guo, Lijiao Xiong, Junbin Xie, Jiwei Zeng, Zhihua Huang, Mengting Yao, Xiaoan Zhang, Jianwen Mo

Institutions: Ganzhou People's Hospital, Guangdong Provincial People's Hospital, Southern University of Science and Technology, ShenZhen People’s Hospital, Gannan Medical University, First Affiliated Hospital of Gannan Medical University

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4402680132

FWCI: 0.417

Cites: 33

Cited by: 3

Related to: 10