The Role of Gut Microbiome in Autism Spectrum Disorder (ASD) and Emerging Treatment Strategies
Year: 2024
Type: article
Study design: Systematic Review
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder. It is distinguished by repetitive behaviors, trouble in social interaction, and difficulty in communication. Recent research has demonstrated a strong association between gut microbiota and ASD. The purpose of this review is to highlight the relationship between the gut microbiome and autism spectrum disorder and how variations in the gut microbiome lead to severe psychological and autistic symptoms. We conducted a systematic review following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines, reviewing experimental and epidemiological studies from the last decade (2013-2023). Google Scholar and PubMed were used for data collection. This review includes a total of 37 studies from the past decade. Our findings revealed that individuals with ASD often had variations in their gut microbiome composition, and these distinct compositions are associated with behavioral symptoms and many gastrointestinal (GI) problems. The connection between the gut and the brain has demonstrated promising potential. These connections help scientists to come up with new interventions and potential treatments. By using microbiota transfer therapy (MTT), probiotics, and manipulating the gut microbiome through exclusive diets, there is a possibility that we can positively impact ASD patients' social and GI problems. In conclusion, further studies are essential to explore specific gut microbiota and their mechanisms linking the gut and brain. Such research could lead to better treatment opportunities and improve the quality of life for people with autism spectrum disorder.
Authors: Raphael Ijeokwu, Simran Goraya, Hassan Muhammed Ul Haq, Rufus Okocha, Roshan Goswami, Elijah Oluwasegun Ayoigbala Adetunji, Mohammed Nawazuddin, Oghenerukevwe Faith Ohwodo, Shazia Noreen Durrani, Ayesha Taqi, Ademilua Oluwatobi Iyanuoluwa, Andeebia Ayub Khan, Olasumbo Elizabeth Fagbenle, Ogochi Blessing Chukwuneke, Patrick Batti, Jovita Echere
Institutions: American University of Barbados, Kharkiv National Medical University, Jinnah Sindh Medical University, American University of Antigua, Dow University of Health Sciences, All Saints University School of Medicine, Foundation University Medical College, Windsor University School of Medicine, The University of Texas Health Science Center at Houston
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4402685023