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Bi-Level Optimization to Enhance Intensity Modulated Radiation Therapy Planning

Year: 2024
Type: article
Abstract: Intensity Modulated Radiation Therapy is an effective cancer treatment. Models based on the Generalized Equivalent Uniform Dose (gEUD) provide radiation plans with excellent planning target volume coverage and low radiation for organs at risk. However, manual adjustment of the parameters involved in gEUD is required to ensure that the plans meet patient-specific physical restrictions. This paper proposes a radiotherapy planning methodology based on bi-level optimization. We evaluated the proposed scheme in a real patient and compared the resulting irradiation plans with those prepared by clinical planners in hospital devices. The results in terms of efficiency and effectiveness are promising.
Source: Informatica
DOI: 10.15388/24-infor560
Authors: Juan José Moreno, Savíns Puertas-Martín, Juana L. Redondo, Pilar M. Ortigosa, Anna Zawadzka, Pawel Kukołowicz, Robert Szmurło, Ignacy Kaliszewski, Janusz Miroforidis, Ester M. Garzón
Institutions: University of Almería, University of Sheffield, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw University of Technology, Systems Research Institute, Polish Academy of Sciences
Language: English
Subfield: Radiation
Open Access status: hybrid
Awards: G1554683258, G2262748287, G3480869486, G3681454997, G4042783231, G4193263096, G425668148, G451917667, G5967599077
OpenAlex ID: W4402685404
FWCI: 0.865
Cites: 29
Cited by: 3
Related to: 10