Arylation of 2‐Chloro‐3‐(4,6‐Diaryl‐1,3,5‐Triazin‐2‐yl) Quinolines: Formal Synthesis of 3‐(4,6‐Diaryl‐1,3,5‐Triazin‐2‐yl)‐2‐Substituted Quinolines by Suzuki–Miyaura Reaction
Year: 2024
Type: article
Abstract: ABSTRACT We have described herein a simple and formal two‐step synthesis of 3‐(4,6‐diaryl‐1,3,5‐triazin‐2‐yl)‐2‐aryl quinolines from 2‐chloro‐3‐(4,6‐diaryl‐1,3,5‐triazin‐2‐yl) quinolines and boronic acids under the Suzuki–Miyaura conditions. This protocol provides the C‐2 arylation of 2‐chloro‐3‐(4,6‐diaryl‐1,3,5‐triazin‐2‐yl) quinolines under the mild reaction conditions. These newly formed chemo‐types may be useful in drug discovery programs or in material chemistry.
DOI: 10.1002/jhet.4909
Institutions: Yonsei University, Umm al-Qura University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Funder: Yonsei University
OpenAlex ID: W4402688017