Work

Macrophages-derived high-mobility group box-1 protein induces endothelial progenitor cells pyroptosis

Year: 2024

Type: article

Abstract: to isolate EPCs for better observation. By detecting the pyroptosis-related indicators of EPCs and the level of release and acetylation of HMGB1 in inflammatory macrophages, it was found that HMGB1 released by inflammatory macrophages combined with receptor for advanced glycation end products (RAGE) is a key pathway to induce pyroptosis of EPCs.

Source: iScience

DOI: 10.1016/j.isci.2024.110996

Authors: Menghao Zeng, Guibin Liang, Fangfang Yuan, Shanshan Yan, Jie Liu, Zhihui He

Institutions: Central South University, Third Xiangya Hospital, National Engineering Research Center of Human Stem Cells

Language: English

Topic: Advanced Glycation End Products research

Subfield: Clinical Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,150