Year: 2024
Type: article
Abstract: Nicotinamide adenine dinucleotide (NAD + ) is crucial for cellular energy production, serving as a coenzyme in oxidation-reduction reactions. It also supports enzymes involved in processes such as DNA repair, aging, and immune responses. Lower NAD + levels have been associated with various diseases, highlighting the importance of replenishing NAD+. Nicotinamide phosphoribosyltransferase (NAMPT) plays a critical role in the NAD + salvage pathway, which helps sustain NAD + levels, particularly in high-energy tissues like skeletal muscle.This review explores how the NAMPT-driven NAD + salvage pathway influences skeletal muscle health and functionality in aging, type 2 diabetes mellitus (T2DM), and skeletal muscle injury. The review offers insights into enhancing the salvage pathway through exercise and NAD + boosters as strategies to improve muscle performance. The findings suggest significant potential for using this pathway in the diagnosis, monitoring, and treatment of skeletal muscle conditions.
Authors: Mengzhu Su, Fanghui Qiu, Yansong Li, Tongtong Che, Ningning Li, Shuangshuang Zhang
Institutions: Qingdao University, Affiliated Hospital of Qingdao University
Language: English
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,295
OpenAlex ID: W4402692841