Saccadic oscillations as a possible indicator of dizziness due to choline esterase inhibitors: an observational study with video-oculography
Year: 2024
Type: article
Study design: Case Report
Abstract: Introduction: Cholinesterase inhibitors (ChEIs) are widely used to treat mild to moderate Alzheimer disease and vascular dementia. Even though dizziness due to medication of ChEIs has been ascribed to adverse effects on the cardiovascular or central nervous system, the mechanisms remain unclear and objective indicators are not available. Methods: We recorded the eye movements using video-oculography in three patients who developed dizziness and unsteadiness after initiation or increment of ChEI, donepezil (Aricept). Results: The patients showed frequent saccadic oscillations that improved after discontinuation of ChEI. Conclusions: Frequent saccadic oscillations may be an indicator of dizziness in patients taking ChEIs.
Source: Research in Vestibular Science
Authors: Ileok Jung, Moon-Ho Park, Ji-Soo Kim
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4402694109