Expression feature and prognostic function of a novel immune checkpoint Siglec-15 in human colorectal cancer.
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Sialic acid-bound immunoglobulin lectin 15 (Siglec-15) plays an important role in the development of cancer. However, the association between Siglec-15 expression and clinicopathological characteristics of colorectal cancer (CRC) has not been fully investigated. METHODS: In this present study, a number of bioinformatics analyses were performed to provide an overview and detailed characteristics of Siglec-15. Quantitative real-time polymerase chain reaction (qPCR), western blotting and immunohistochemistry analyses were conducted to characterize the expression of Siglec-15 in CRC. Kaplan-Meier survival and Cox regression analyses were performed to identify the prognostic parameters of CRC. RESULTS: =0.003) were independent prognostic factors for CRC. CONCLUSIONS: Collectively, the data suggested that Siglec-15 expression may serve as a novel prognostic factor and Siglec-15 might be identified as an ideal candidate for immunotherapy in CRC treatment.
Source: PubMed
DOI: 10.14670/hh-18-801
Authors: Guodong Liang, Linyun Zhou, Yang Fan, Run Ding, Junrong Yang, Li Xu, Yidan Zhu, Wen Huang
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4402697784