Multiscale and multimodal evaluation of autosomal dominant polycystic kidney disease development
Year: 2024
Type: article
Abstract: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most prevalent kidney genetic disorder, producing structural abnormalities and impaired function. This research investigates its evolution on mouse models, utilizing a combination of histology imaging, Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) to evaluate its progression thoroughly. ADPKD has been induced in mice via PKD2 gene knockout, followed by image acquisition at different stages. Histology data provides two-dimensional details, like the cystic area ratio, whereas CT and MRI facilitate three-dimensional temporal monitoring. Our approach allows to quantify the affected tissue at different disease stages through multiple quantitative metrics. A pivotal point is shown at approximately ten weeks after induction, marked by a swift acceleration in disease advancement, and leading to a notable increase in cyst formation. This multimodal strategy augments our comprehension of ADPKD dynamics and suggests the possibility of employing higher-resolution imaging in the future for more accurate volumetric analyses. Studies of ADPKD progression in mouse models using histology, CT, and MRI to monitor disease evolution reveals a significant acceleration in cyst formation around ten weeks post-induction, underscoring the utility of multimodal imaging for detailed analysis of disease stages.
Source: Communications Biology
Institutions: Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Carlos III de Madrid, Hospital Universitario Fundación Jiménez Díaz, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Centro de Investigación Médica Aplicada, Universidad de Navarra, Universidad Rey Juan Carlos, Centro de Investigación Biomédica en Red de Salud Mental
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,890
Awards: G1105844351, G1175115578, G1277142030, G1341303, G1539862780, G1622782223, G2018790313, G2086039145, G2262748287, G2648084224, G2649219557, G2672435700, G2673512141, G300979063, G3017560398, G34346518, G3480869486, G3595463749, G3722519122, G410571670, G425668148, G451917667, G4526231891, G4603983426, G491712853, G495282969, G5080475149, G5404395142, G5539308778, G5555131222, G5635532810, G5829384225, G5967599077, G624877701, G7084143925, G7434936867, G7573077907, G7805626310, G7863371703, G8137395159, G8293798641, G8497050386, G8684520763, G8696694383, G8796229591, G8961273746, G929308097
OpenAlex ID: W4402697825