The role of CD24hiCD27+ regulatory B cells in human chronic rhinosinusitis with/without nasal polyps
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Regulatory B cells (Bregs) reduce allergic and autoimmune inflammation. However, their role in chronic rhinosinusitis (CRS) remains unknown. This study investigated the frequency and function of Breg subsets in the peripheral blood of patients with CRS. METHODS: B cells (B10 cells) were isolated by flow cytometry, followed by RNA sequencing (RNA-seq). Finally, IL-10 secreted by B10 cells were evaluated through the intracellular stain. RESULTS: B10 cells in peripheral blood was lower in patients with eCRSwNP than in the neCRSwNP and control groups. CONCLUSION: B10 cells may play a key role in the pathological mechanisms of CRS, particularly the recurrence of eCRSwNP.
Source: Immunobiology
Authors: Shiyu Tian, Jiao Xia, Ke Liu, Youxiang Ma, Hao Tian, Weiwei Wang, Ruxiang Zhang, Chunli Zhao, Shusheng Gong
Institutions: Capital Medical University, Beijing Friendship Hospital
Language: English
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,500
OpenAlex ID: W4402698315