Inhibition of IgE and IgG1 expression in BALB/c mice and clionasterol potential bioactivity evaluation in Dioscorea alata extract, in vivo and in silico studies
Year: 2024
Type: article
Abstract: The prevalence of allergic diseases worldwide is rising dramatically in both developed and developing countries.Dioscorea alata (DA) contains flavonoids and saponin steroid which have potential as anti-allergic agents.This research aims to examine the anti-allergy potential of the ethanol extract of Dioscorea alata (EEDA) through IgE and IgG1 levels and to investigate the bioactivity of the phytocompound of hexane extract of D. alata (HEDA) in silico.Allergy-induced BALB/c mice used Ovalbumin and were treated with EEDA for 30 days.The levels of B220IgE and B220IgG1 were evaluated.In silico analysis was conducted with HEDA, phytocompound from previous research, 3D structure from PubChem (https://pubchem.ncbi.nlm.nih.gov/),Chemspider (http://www.chemspi-der.com/),Bioactivity analysis on Molinspiration
DOI: 10.54319/jjbs/170302
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4402698849