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Chemotherapy-Induced Cutaneous Sclerosis: A Rare Clinical Finding

Year: 2024

Type: article

Abstract: Scleroderma-like cutaneous sclerosis has been reported as a rare adverse reaction to several drugs, including the chemotherapeutical agent paclitaxel, used in therapeutic regimens for several malignancies. The sclerosis is usually limited to the skin, most commonly presenting in the lower limbs after weeks to months of therapy but is often refractory to treatment and progresses even after discontinuation of the offending agents, with significant resulting morbidity. We report a rare case of severe cutaneous sclerosis secondary to chemotherapy with nab-paclitaxel and gemcitabine, which did not respond to treatment and led to discontinuation of chemotherapy.

Source: Cureus

DOI: 10.7759/cureus.69870

Authors: Duarte Flor, Joana a Calvão, Edgar Pratas, Inês Coutinho, Jose C Cardoso

Institution: Unidade Local de Saúde de Coimbra

Language: English

Topic: Chemotherapy-related skin toxicity

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4402702704