Work

Copper‐Catalyzed Aerobic Cross‐Dehydrogenation Coupling of Indoles for Synthesis of 2,3′‐Bisindoles

Year: 2024

Type: article

Abstract: 2,3'-Bisindoles with C-C linkages have attracted interest in medicinal chemistry, yet their synthesis is intricate with many steps. Notably, direct C-H/C-H cross-coupling of non-directed heteroaromatics remains challenging, often requiring precious metals and oxidants to enhance coupling efficiency. Herein, we present a copper-catalyzed C-H/C-H cross-coupling method for N-substituted indoles without directing groups, facilitated by molecular oxygen under gentle conditions. It showed reasonable functional group compatibility and provided one-pot access to a variety of 2,3'-bisindoles derivatives in moderate to good yields.

Source: Chemistry - An Asian Journal

DOI: 10.1002/asia.202401015

Authors: Xinxiang Huang, Yingying Yang, Qiping He, Chang Liu, Mingquan Yuan, Yi Jin

Institution: Yunnan University

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Yunnan University

Awards: G1267853476, G2724482189, G4138020067