Year: 2024
Type: article
Abstract: N1-methyladenosine (m1A) is a very rare RNA modification in mammalian mRNA, which occurs in sequences resembling the T-loop of tRNAs and may not have significant effects on gene expression. A new study in this issue now reports that m1A is abundant and dynamic in the 3′UTR of mRNAs of dinoflagellates, and could have an important role in post-transcriptional gene expression regulation in these organisms. Unlike the scarce presence in typical eukaryotes, m1A is prevalent in dinoflagellate mRNA, m1A levels correlate with the expression of metabolism-related genes and respond to nitrogen starvation.
Source: EMBO Reports
Authors: Jianheng Fox Liu, Samie R Jaffrey
Institutions: Cornell University, Weill Cornell Medicine
Language: English
Topic: RNA modifications and cancer
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,890
OpenAlex ID: W4402713446