Work

Effect of the Jiedu Tongluo Shengjin formulation on plasma immunoglobulin G (IgG) levels in patients with primary Sjögren’s syndrome

Year: 2024

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: This study assessed the effect of Jiedu Tongluo Shengjin formulation on plasma IgG levels in pSS patients. 89 pSS patients were randomized into treatment (45 cases; 1 drop-out) and control (44 cases) groups using the random number table method. The control group received hydroxychloroquine sulfate and a placebo dose of Jiedu Tongluo Shengjin. The treatment group received hydroxychloroquine sulfate and the original Jiedu Tongluo Shengjin formulation. The treatment group showed significant decreases in SS disease activity index, TCM syndrome score, plasma IgG, and ESR, and significant increases in tear film break-up time, tear flow rate, salivary flow rate, C3, and C4 levels (p<0.05). No significant changes were observed in the control group (p>0.05). Jiedu Tongluo Shengjin effectively reduced eye and mouth dryness in pSS patients by improving inflammation and immune status.

Source: Boletin Latinoamericano y del Caribe de plantas Medicinales y Aromaticas

DOI: 10.37360/blacpma.25.24.1.1

Authors: Yong-Sheng Ou, Ya-Le Wang, Pan-Pan Zheng, Luan Xue, Fang-Ying Gao

Institutions: Shanghai Pulmonary Hospital, Shanghai University of Traditional Chinese Medicine, Yueyang Hospital

Language: English

Topic: Salivary Gland Disorders and Functions

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4402720955

FWCI:

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