Work

Quantitative Analysis of Hematopoietic and Leukemic Stem Cell Dynamics in Acute Myeloid Leukemia: A Mathematical Approach

Year: 2024

Type: article

Abstract: This study aims to unravel the growth dynamics of hematopoietic and leukemic stem cells within the bone marrow, viewing them as a complex network of interconnected compartments representing distinct stages of cellular differentiation. Leveraging insights from established models of cancer cell growth, we have undertaken a comprehensive re-examinations and reinterpretation of some classical growth models, subsequently reformulating them into a fractional order derivative-based framework. Employing this innovative approach, we have delved into the intricate interplay between self-renewal and proliferation rates across diverse sub-stages of cellular differentiation. Our investigations illuminate the nuanced regulatory mechanisms governing stem cell dynamics, offering significant insights into the pathophysiology of hematopoietic disorders, notably acute myeloid leukemia.

Source: INTERNATIONAL JOURNAL OF MATHEMATICS AND COMPUTER RESEARCH

DOI: 10.47191/ijmcr/v12i9.02

Authors: Sapna Ratan Shah, Ashik Babu Parambath, Kavita Arora

Institutions: Jawaharlal Nehru University, Advanced Instrumentation Research Facility

Language: English

Topic: Mathematical Biology Tumor Growth

Subfield: Modeling and Simulation

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4402724272

FWCI:

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