Work

ZNF197-AS1/miR-425/GABARAPL1 axis: a novel regulatory mechanism in uveal melanoma

Year: 2024

Type: article

Abstract: This study identifies the ZNF197-AS1/miR-425/GABARAPL1 axis as a novel regulatory mechanism in uveal melanoma. ZNF197-AS1 upregulates GABARAPL1 by sponging miR-425, inhibiting UM cell proliferation, migration, and invasion. This discovery highlights a potential therapeutic target, providing new insights into UM progression and patient outcomes.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00457.2024

Authors: Chao Zhang, Shuai Wu

Institutions: Jilin University, Second Affiliated Hospital of Jilin University

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4402725698

FWCI: 0.465

Cites: 55

Cited by: 3

Related to: 10