Metabolic Syndrome: in Vitroantioxidant, Anticancer, Anti-inflammatory and Antimicrobial Activities of Dissotis Rotundifolia(sm.) With Phytochemical and Nutritional Components
Year: 2024
Type: article
Abstract: Background:Dissotis rotundifolia(Sm.) Triana isa prostrate herb of the family Melastomataceae. It is used for the treatment of obesity, hypertension, circulatory problems and metabolic syndrome (MS). This study evaluated the antioxidant, anticancer, anti-inflammatory.and antimicrobial activities of the whole plant of D. rotundifoliato validateits therapeutic potential in the management and treatment of MS. Materials and Methods: The plant was screened for proximate, mineral, vitamin and phytochemical components, as well as antioxidant activities using standard laboratory techniques. The anticancer activities of the ethanol plant extract were against kidney (VERO) and breast (MCF-7) cancer cells. The anti-inflammatory activity of the extract was determined using nitric oxide production inhibition assay and the antimicrobial activity was evaluated against five pathogenic organisms. All data were subjected to statistical analysis. Results: The plant was rich in carbohydrate (47.87%), protein (22.5%), crude fibre (9.57%), Na (206.67 mg/100 g), Ca (183.33mg/100 g), vitamin C (25.53 mg/100 g), flavonoids (685.00 mg/100 g), alkaloids (616.67 mg/100 g) and saponins (471.67 mg/100 g) contents. Theextract exhibited considerableand variedantioxidant activities.The plant extract was very active against VERO and MCF-7 cellsatlow concentrations(0.145 mg/ml and 0.141 mg/ml respectively) compared to doxorubicin. It also exhibited significant anti-inflammatory action against lipopolysaccharide (LPS)-stimulated RAW macrophage. The extract was active against all test organisms. Overall, D. rotundifolia displayed significant antioxidant, anticancer, anti-inflammatory and antimicrobial activities. Conclusion: The observed bioactivities of the plant could be attributed to its phytocontents and are indications of itspotential as an agent for the managementand treatment ofmetabolic syndrome.
Authors: Idayat Titilayo GBADAMOSI, Joseph Ayotunde BADEJO, Temitayo Olabisi AJIBADE, Akpevwoghene AGBATUTU, Ezekiel Ayodeji ABIARA, Akinlolu Tobi AKINKOYE, Emmanuel Oloruntoba YEYE, Ibukun Michea FAMUYIDE, Lyndy Joy MCGAW, Sanah Malomile NKADIMENG, Ademola Adetokunbo OYAGBEMI, Temidayo Olutayo OMOBOWALE, Akindele Oluwatosin ADEYI, Oluwatoyin Adepeju ODEKU, Aishat Mojisola AKERE, Jemilat Aliyu IBRAHIM, Taoheed Kolawole MUFTAUDEEN
Institutions: University of Ibadan, University of South Africa
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
Funder: Tertiary Education Trust Fund
OpenAlex ID: W4402728408