Work

Synthesis and in vitro screening of benzo[h]coumarinyl heterocycles as promising antibacterial agents

Year: 2024

Type: article

Abstract: In this study, benzo[h]coumarin and the corresponding substituted chalcones were designed and synthesized. These compounds have been used as a precursor to prepare various heterocyclic compounds like pyrimidines, pyrazole, pyrazole-1-carbothioamide, diazepines, oxazepines, isoxazoles and epoxides. The structures of the synthesized compounds were confirmed by FT-IR, 1H and 13C-NMR spectroscopy. These target heterocyclic derivatives were biologically screened against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) pathogenic bacteria. The best obtained result was for compound (6b) against S. aureus, Gram-positive bacteria. KEY WORDS: Benzo[h]coumarin, heterocyclic compounds, antibacterial activity Bull. Chem. Soc. Ethiop. 2024, 38(6), 1815-1826. DOI: https://dx.doi.org/10.4314/bcse.v38i6.24

Source: Bulletin of the Chemical Society of Ethiopia

DOI: 10.4314/bcse.v38i6.24

Authors: Abdallah. F. Al burgus, Omar T. Ali, Omar Y. Mohammad

Institution: University of Mosul

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: University of Mosul