Year: 2024
Type: article
Study design: Observational Study
Abstract: PURPOSE: Prospective, multicentric observational cohort study in Switzerland investigating measures to prevent mother-to-child transmission in pregnant women with HIV (WWH) and assessing health and development of their exposed children as well as of children with HIV (CWH) in general. PARTICIPANTS: Between January 1986 and December 2022, a total of 1446 mother-child pairs were enrolled. During the same period, the study also registered 187 CWH and 521 HIV-exposed but uninfected children (HEU), for whom detailed maternal information was not available. Consequently, the cohort comprises a total of 2154 children. FINDINGS TO DATE: During these 37 years, research by the Swiss Mother and Child HIV Cohort Study (MoCHiV) and its international collaborators has strongly influenced the prevention of vertical transmission of HIV (eg, introduction and discontinuation of elective caesarean section, neonatal postexposure prophylaxis and breastfeeding). Contributions have also been made to the management of diagnostics (eg, p24 antigen assay) and the effects of antiretroviral treatment (eg, prematurity, growth) in HEU and CWH. FUTURE PLANS: . In addition, analyses are planned on the longitudinal health status of CWH (eg, resistance and prolonged exposure to antiretroviral therapy), on social aspects including stigma in CWH and HEU, and on interventions to further optimise antenatal and postpartum care in WWH.
Source: BMJ Open
Authors: Paolo Paioni, Murezi Capaul, Anja Brunner, Anna Traytel, Karoline Aebi-Popp, Pierre-Alex Crisinel, Andrea Duppenthaler, Huldrych Günthard, Begona Martinez De Tejada, Lisa Kottanattu, Marcel Stöckle, Andri Rauch, Noemie Wagner, Irene Hösli, Christoph Rudin, Alexandra Scherrer, Katharina Kusejko, Christian R Kahlert
Institutions: University Children's Hospital Zurich, University of Zurich, University Hospital Zurich, University of Bern, University Hospital of Bern, Stiftung Lindenhof Bern, Lindenhofspital, Centre Hospitalier Universitaire Vaudois, University of Lausanne, University of Geneva, University Hospital of Geneva, Istituto Pediatrico della Svizzera Italiana, University of Basel, University Hospital of Basel, University Children’s Hospital Basel, Kantonsspital St. Gallen, Ostschweizer Kinderspital
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,868
Award: Swiss HIV Cohort Study
OpenAlex ID: W4402730794