Year: 2024
Type: article
Abstract: Margination, the migration of leukocytes to the vessel wall, is a well-known physiological process. However, the role of cell stiffness in this phenomenon remains unclear. Our study investigates the segregation of stiffened red blood cells (RBCs) within healthy cell suspensions. Unexpectedly, we found central and corner peaks in the stiffened RBC distribution and a nonmonotonic dependency on the flow rate. Length scales for margination are found to be much longer than typical distances between bifurcations in-vivo, questioning the importance of margination in physiological situations.
Source: Physical Review Fluids
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4402731671