Work

A polymer nanogel-based therapeutic nanovaccine for prophylaxis and direct treatment of tumors via a full-cycle immunomodulation

Year: 2024

Type: article

Abstract: could also activate STING in tumors to synergize with ICD for potentiated immune responses. Overall, the biomimetic NG-based therapeutic nanovaccine could directly evoke immune system, and also conduct local tumor treatment to further activate ICD, thus realizing a full-cycle immunomodulation (tumor killing for ICD/antigen production, and tumor cells/APCs immune activation) to tackle bilateral tumor growth.

Source: Bioactive Materials

DOI: 10.1016/j.bioactmat.2024.09.024

Authors: Yunqi Guo, Zhiqiang Wang, Gaoming Li, Mengsi Zhan, Tingting Xiao, Jianhong Wang, Jan C.M. van Hest, Xiangyang Shi, Mingwu Shen

Institutions: Donghua University, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai University of Engineering Science, Eindhoven University of Technology

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,200

Funders: National Natural Science Foundation of China, Ministerie van Onderwijs, Cultuur en Wetenschap, Science and Technology Commission of Shanghai Municipality

Awards: G2292308301, G3091697161, G3667673549, G390116814, G6330235322, G6823177778, G6898580520, G7188269812

OpenAlex ID: W4402737774

FWCI: 2.722

Cites: 50

Cited by: 20

Related to: 10