Cuparene-type sesquiterpenes with neuroprotective activities from the edible mushroom Flammulina filiformis
Year: 2024
Type: article
Abstract: Four new cuparene-type sesquiterpenes , flammuterpenols A − D ( 1 – 4 ), along with one known congener ( 5 ) were isolated from the solid culture of edible mushroom Flammulina filiformis. Their structures with a benzoxabicyclo[3.2.1]octane core were elucidated by integrated multiple spectroscopic techniques, electronic circular dichroism , and single crystal X-ray diffraction analysis. Biologically, compounds 1 – 5 were evaluated in vitro for their neuroprotective effects against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells. All of them exhibited remarkable neuroprotective effects possessing the EC 50 values ranging from 0.93 ± 0.02 to 10.28 ± 0.10 μM. These findings not only enrich the structural diversity of cuparene-type sesquiterpenes , but also provide potential candidates for the further development of the neuroprotective agents .
Source: Fitoterapia
Authors: Shouyuan Wu, Xianqiang Chen, Jingling Ren, Peilian Liu, Qing Yan, Ziming Chen
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,830
OpenAlex ID: W4402738879