An Advanced Database for GlycoPeptide Structure Exploration to build GlycoPeptideStructure Hub: GPS Hub
Year: 2024
Type: conference-paper
Abstract: Using PDB experimental structures, a new database named GPS Hub is proposed.We define a sequon as an 11-mer peptide that spans from positions -5 to +5 relative to the central glycosylation site.We identified 87050 sequons and using machine learning techniques, in particular UMAP and DBSCAN algorithms, we clustered them into 2625 distinct groups.Below, we present the key findings for three of these clusters.We have developed a database that consolidates comprehensive information on sequon and Glycan structures, starting from experimental data.We employed a machine learning approach to categorize these structures into clusters, uncovering common patterns hidden within glycan sequences.
Source: European Peptide Symposium (EPS)
Institution: University of Florence
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4402744703