Get started
Work

Redistribution of SOD3 expression due to R213G polymorphism affects pulmonary interstitial macrophage reprogramming in response to hypoxia

Year: 2024
Type: article
Abstract: Redistributed expression of SOD3 out of tissue ECM due to the human R213G SNP exacerbates chronic hypoxic PH. Highlighting the importance of macrophage phenotype, our findings reveal that the R213G SNP does not exacerbate pulmonary macrophage accumulation in response to hypoxia but influences their metabolic and phenotypic reprogramming. We demonstrate a deficiency in the metabolic response to hypoxic stress in R213G macrophages, associated with weakened inflammatory resolution and activation of profibrotic pathways implicated in PH.
DOI: 10.1152/physiolgenomics.00078.2024
Authors: Caitlin V. Lewis, Anastacia M. Garcia, Samuel D. Burciaga, Janelle N. Posey, Mariah Jordan, Thi-Tina N. Nguyen, Kurt R. Stenmark, Claudia Mickael, Christina Sul, Cassidy Delaney, Eva S. Nozik
Language: English
Field: Medicine
Open Access status: green
Awards: Redox regulation of hyaluronan-macrophage interactions and macrophage reprogramming in pulmonary hypertension, G4148593637, G474972328, G5841849987, G7273972805, G9000138239
OpenAlex ID: W4402746542
FWCI: 1.016
Cites: 70
Cited by: 4
Related to: 10