Exercise and tumor proteome: insights from a neuroblastoma model
Year: 2024
Type: article
Abstract: We used liquid chromatography with tandem mass spectrometry to explore the impact of a 5-wk exercise intervention on the tumor proteome profile in a mouse model of one of the most aggressive childhood malignancies, high-risk neuroblastoma. Exercise altered the abundance of hundreds of proteins and pathways, particularly those involved in energy metabolism and tumor suppression. These molecular changes could mediate, at least partly, the potential antitumorigenic effects of exercise.
Source: Physiological Genomics
Authors: Abel Plaza-Florido, Beatriz G. Gálvez, Juan A. López, Alejandro Santos-Lozano, Sandra Zazo, Cecilia Rincón-Castanedo, Asunción Martín-Ruiz, Jorge Lumbreras, Laura C. Terron-Camero, Alejandro López-Soto, Eduardo Andrés-León, África González-Murillo, Federico Rojo, Manuel Ramírez, Alejandro Lucia, Carmen Fiuza-Luces
Institutions: University of California, Irvine, Universidad Complutense de Madrid, Research Institute Hospital 12 de Octubre, Instituto de Salud Carlos III, Spanish National Centre for Cardiovascular Research, Centro de Investigación Biomédica en Red, Universidad Europea Miguel de Cervantes, Hospital Universitario Fundación Jiménez Díaz, Centro de Investigación Biomédica en Red de Cáncer, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Universidad Nebrija, Consejo Superior de Investigaciones Científicas, Instituto de Parasitología y Biomedicina "López - Neyra", Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Universidad Europea de Madrid
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4402747191