Work

Advances in the synthesis of C19-hydroxylated steroids

Year: 2024

Type: article

Abstract: The significant medicinal values associated with C19-hydroxylated steroids dictate a growing demand for new synthetic strategies that would provide facile access to these challenging targets. This review will encapsulate the key synthetic strategies for C19-hydroxylated steroids, which include indirect C–H oxidation and direct C–H oxidation in semi-synthesis as well as total synthesis. The significant medicinal values associated with C19-hydroxylated steroids dictate a growing demand for new synthetic strategies that would provide facile access to these challenging targets. This review encapsulates the key synthetic strategies for C19-hydroxylated steroids, which include indirect and direct steroidal C19–H hydroxylation involved semisynthesis as well as total synthesis from simple building blocks.

Source: Green Synthesis and Catalysis

DOI: 10.1016/j.gresc.2024.09.004

Authors: Dongkai Wang, Lan Zhou, Fuzhen Song, Qianghui Zhou

Institutions: Ministry of Education of the People's Republic of China, Wuhan University

Language: English

Topic: Steroid Chemistry and Biochemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: National Natural Science Foundation of China, Wuhan University

Award: G8361356539