Work

Photoacoustic thermal-strain measurement towards noninvasive and accurate temperature mapping in photothermal therapy

Year: 2024

Type: article

Abstract: Photothermal therapy is a promising tumor treatment approach that selectively eliminates cancer cells while assuring the survival of normal cells. It transforms light energy into thermal energy, making it gentle, targeted, and devoid of radiation. However, the efficacy of treatment is hampered by the absence of accurate and noninvasive temperature measurement method in the therapy. Therefore, there is a pressing demand for a noninvasive temperature measurement method that is real-time and accurate. This article presents one such attempt based on thermal strain photoacoustic (PA) temperature measurement. The method was first modelled, and a circular array-based photoacoustic photothermal system was developed. Experiments with Indian ink as tumor simulants suggest that the temperature monitoring in this work achieves a precision of down to 0.3 °C. Furthermore, it is possible to accomplish real-time temperature imaging, providing accurate two-dimensional temperature mapping for photothermal therapy. Experiments were also conducted on human fingers and nude mice, validating promising potentials of the proposed method for practical implementations.

Source: Photoacoustics

DOI: 10.1016/j.pacs.2024.100651

Authors: Zezheng Qin, Puxiang Lai, Mingjian Sun

Institutions: Harbin Institute of Technology, Suzhou Research Institute, Hong Kong Polytechnic University

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,810