Work

Organotellurium (IV) complexes as anti-malarial agents: synthesis, characterization and computational insights

Year: 2024

Type: article

Abstract: Aim: To synthesize and evaluate the antimalarial and antioxidant activities of novel organotellurium (IV) thiophene-based complexes.Materials & methods: Synthesized complexes were characterized using NMR, IR and mass spectrometry. Their biological activities were assessed using in vitro assays and molecular docking studies.Results: The complexes exhibited significant antimalarial activity against Plasmodium falciparum, with the highest activity observed for complexes 5b and 5e. ADMET properties confirmed their potential as therapeutic agents.

Source: Future Medicinal Chemistry

DOI: 10.1080/17568919.2024.2401310

Authors: Anisha Bhardwaj, Amit Dubey, Aisha Tufail, Nasir Tufail, Manish Kumar, Sapana Garg

Institutions: Maharshi Dayanand University, Saveetha University, Prof. Rajendra Singh (Rajju Bhaiya) University

Language: English

Topic: Organoselenium and organotellurium chemistry

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4402749715