Integration of QSAR and NAM in the Read-Across Process for an Effective and Relevant Toxicological Assessment
Year: 2024
Type: book-chapter
Abstract: Read-Across (RAx) serves as a strategy to fill a data gap in the toxicological profile of a substance (target) using existing information on similar source substances. The principle is applied also to a category of substances for which similarity may follow a regular trend. Demonstration of similarity is not trivial and requires the analysis of different steps, starting from the precise analytical characterization of both target and source substances and including the analysis of the impact that each minor difference can have on the final outcome. Application of QSARs and performing new experimental tests within the new approach methodologies (NAMs) is necessary to increase confidence in the final prediction and reduce the uncertainty.
Source: Methods in molecular biology
Authors: Costanza Rovida, Marina Muscarella, Monica Locatelli
Institution: University of Konstanz
Language: English
Subfield: Computational Theory and Mathematics
Field: Computer Science
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W4402749799