Year: 2024
Type: review
Abstract: Antimicrobial resistance (AMR), frequently considered a major global public health threat, requires a comprehensive understanding of its emergence, mechanisms, advances, and implications. AMR's epidemiological landscape is characterized by its widespread prevalence and constantly evolving patterns, with multidrug-resistant organisms (MDROs) creating new challenges every day. The most common mechanisms underlying AMR (i.e., genetic mutations, horizontal gene transfer, and selective pressure) contribute to the emergence and dissemination of new resistant strains. Therefore, mitigation strategies (e.g., antibiotic stewardship programs-ASPs-and infection prevention and control strategies-IPCs) emphasize the importance of responsible antimicrobial use and surveillance. A One Health approach (i.e., the interconnectedness of human, animal, and environmental health) highlights the necessity for interdisciplinary collaboration and holistic strategies in combating AMR. Advancements in novel therapeutics (e.g., alternative antimicrobial agents and vaccines) offer promising avenues in addressing AMR challenges. Policy interventions at the international and national levels also promote ASPs aiming to regulate antimicrobial use. Despite all of the observed progress, AMR remains a pressing concern, demanding sustained efforts to address emerging threats and promote antimicrobial sustainability. Future research must prioritize innovative approaches and address the complex socioecological dynamics underlying AMR. This manuscript is a comprehensive resource for researchers, policymakers, and healthcare professionals seeking to navigate the complex AMR landscape and develop effective strategies for its mitigation.
Source: Microorganisms
Institutions: Cooperativa de Ensino Superior Politécnico e Universitário, Unidade em Ciências Biomoleculares Aplicadas, Instituto Politécnico de Saúde do Norte - CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Unidade de Investigação em Toxicologia & Uma Só Saúde, Instituto Universitário Militar, Centro de Investigação Desenvolvimento e Inovação da Academia Militar, Unidade Local de Saúde de Entre Douro e Vouga, Universidade do Porto, Rede de Química e Tecnologia, Universidade Técnica do Porto
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,069
Awards: G1240268737, G1348429418, G138060719, G1509028180, G1522114529, G1977608718, G2012127377, G2106522556, G2339299466, G2346795057, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, G2756637201, G2783038177, G2814222956, G3127682330, G332082475, Unidade de Ciências Biomoleculares Aplicadas, G4046065984, Unidade de Ciências Biomoleculares Aplicadas, G4320932625, G4360628376, G4378797157, G4500275458, G5366951229, G5506743709, G567200461, G5832795443, G5868090805, G6113984419, G6119126181, G6463117426, G6625491009, G6997658380, Instituto para a Saúde e a Bioeconomia, G7786427436, G8213652065, G824076568, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, G8963217260, G949874453
OpenAlex ID: W4402750809