Complexation Of Zn2+, Mn2+, Co2+, Fe2+Cations With Cefuroxime (Cephalosporin) And Amoxicillin Antibiotics
Year: 2024
Type: article
Abstract: The intricate interplay between antibiotics and transition metal ions play an important role in drug distribution and efficacy.This study explores the interaction between two commonly used antibiotics, cefuroxime and amoxicillin, with transition metal ions.The complexes formed between these antibiotics and Zn ( II), Mn ( II), Co ( II), and Fe ( II) ions were synthesized and characterized using using High-Performance Liquid Chromatography (HPLC), UV-Vis spectrometry, and Fourier-Transform Infrared spectroscopy (FTIR).FTIR spectra confirmed the formation of metal-antibiotic complexes.HPLC results revealed changes in retention time for complexes compared to individual antibiotics, while UV-Vis spectra also showed peak shift for these complexes.This study provides insights into the behavior of drugs in presence of transition metal ions for understaning drug distribution of these antibiotics.
Source: Kurdish Studies
Author: Malay Kumar Das
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4402770391