Year: 2024
Type: article
Abstract: The modification of tamarind seed polysaccharide has greatly expanded its application in the field of medicine.In this study, lowmolecular-weight chitosan was modified with arginine (Arg) by a simple method.The identification by the Fourier transform infrared spectra (FTIR) showed that Arg was successfully covalently attached to the TSP.Interestingly, Arg-TSP was identified as nanoparticles by atomic force microscopy (AFM) and Scanning electron microscopy (SEM), whose particle size was 75.76 ± 12.07 nm based on Dynamic Light Scattering (DLS) characterization.Then, whether the prepared Arg-CS nanoparticles could encapsulate and deliver siRNA safely was investigated.Arg-TSP was found to be able to encapsulate siRNAs in vitro via electrostatic interaction with siRNA; the Arg-TSP/siRNA complex was safe for L1210 leukemia cells.
Author: Abhishek Kumar Ojha
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4402770418