Supplementary Figure S15 from Integrated genomic and transcriptomic analysis improves disease classification and risk stratification of MDS with ring sideroblasts.
Year: 2024
Type: supplementary-materials
Abstract: In-silico cytometry data validation. A) Experimental workflow and multi parameter flow cytometry gating strategy used to sort Lin+ and Lin- from CD34+ MNC and to explore HSPC composition. B) Scatter plot comparing results from multi-parameter-flow (x-axis) and in-silico cytometry (y-axis) partitioned by megakaryocyte/erythroid progenitors (MEP), granulocyte/macrophage progenitors (GMP) and hemopoietic stem cell (HSC), showing significant concordances for MEP and GMP (Pearson correlation coefficient 0.94 and 0.87, P 0.02 and 0.05, respectively; correlation line and 95% confidence interval are represented in dark and light gray, respectively).
Authors: Gabriele Todisco, Maria Creignou, Elsa Bernard, Ann-Charlotte Björklund, Pedro Luis. Moura, Bianca Tesi, Teresa Mortera Blanco, Birgitta Sander, Monika Jansson, Gunilla Walldin, Indira Barbosa, Susanne E. Reinsbach, Isabel Juliana. Hofman, Christer Nilsson, Tetsuichi Yoshizato, Marios Dimitriou, David Chang, Svanhildur Olafsdottir, Sigita Venckute Larsson, Magnus Tobiasson, Luca Malcovati, Petter Woll, Sten-Eirik W. Jacobsen, Elli Papaemmanuil, Eva Hellström-Lindberg
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4402794861