Figure S1 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Year: 2024
Type: other
Abstract: Analysis of EGR2 and type I IFN pathway regulation in CAR T-cells. (A-C) ATAC-seq tracks of genes associated with dysfunction, type I IFN signaling, and memory differentiation are shown, with differentially accessible regions indicated. D, Heatmap showing expression of exhaustion genes in tonically signaling GD2 and functional CD19 naïve CD8+ CAR-T cells (GSE136891). E, Comparison of EGR2 and type I IFN gene signature scores in central memory CD8+ T-cells expressing a tonically signaling GD2 CAR and control CD19 CAR. CAR T-cells were generated using T-cells from a healthy donor (GSE136891). F, Top transcription factor co-expression signatures overexpressed in CD19 CAR T-cell products of CLL complete responders. G, Comparison of EGR2 and type I IFN signature scores in unstimulated CD19 CAR T-cell products from CLL patients (CR: complete response, PRTD: very good partial response, PR: conventional partial response, NR: no response). H, Comparison of type I IFN and EGR2 module scores in PSMA CAR T-cells from lymphodepleted prostate cancer patients, and their association with in vivo CAR T-cell proliferation and PSA decline.
Authors: In-Young Jung, Robert L. Bartoszek, Andrew J. Rech, Sierra M. Collins, Soon-Keat Ooi, Erik F. Williams, Caitlin R. Hopkins, Vivek Narayan, Naomi B. Haas, Noelle V. Frey, Elizabeth O. Hexner, Donald L. Siegel, Gabriela Plesa, David L. Porter, Adrian Cantu, John K. Everett, Sonia Guedan, Shelley L. Berger, Frederic D. Bushman, Friederike Herbst, Joseph A. Fraietta
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4402805632