Work

Synthesis of Indole‐Fused Eight‐Membered Oxa‐Rings via Palladium‐Catalyzed Asymmetric [4+4] Cycloaddition of Indole‐2,3‐Quinodimethanes with 2‐Alkylidenetrimethylene Carbonates

Year: 2024

Type: article

Abstract: Comprehensive Summary We report a palladium‐catalyzed asymmetric [4+4] cycloaddition reaction between 2‐alkylidenetrimethylene carbonate and electron‐deficient indole‐2,3‐quinodimethanes (IQDMs). This reaction features exclusive regioselectivity, high yield (up to 98%), excellent enantioselectivity (up to 95% ee), and easy scale‐up without any loss of efficiency, making it valuable for the synthesis of indole‐fused eight‐membered oxa‐rings.

Source: Chinese Journal of Chemistry

DOI: 10.1002/cjoc.202400764

Authors: Xinhao Lu, Yi Wang, Chenghan He, Yang‐Zi Liu, Wei‐Ping Deng

Institutions: Zhejiang Normal University, East China University of Science and Technology, Chinese University of Hong Kong, Shenzhen

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Zhejiang Normal University

Awards: G5522427719, G8988554920