Tetrahydropyranyl and Tetrahydrofuranyl as New Backbone Protecting Groups For Enhanced Fmoc SPPS
Year: 2024
Type: conference-abstract
Abstract: Acidic Cleavage Deprotection KineticsTHP and THF protected dipeptides with general structure Fmoc-Gly-(PG)Gly-OH, were reacted in cleavage solutions containing various amounts of TFA, monitored over a 3-hour period. They were compared to the Dmb group and a pseudoproline (Ser(ψ Me,Me Pro)) * motif.Results:• Tetrahydrofuran (THF) is hyper acid-labile• Tetrahydropyran (THP) can be removed in mild cleavage cocktails • Order of reactivity; THF > ψ Me,Me Pro > THP > Dmb
Source: European Peptide Symposium (EPS)
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4402812653