Work

Scoring the Synthesizability of Any Novel Non-natural Amino Acid

Year: 2024

Type: conference-paper

Abstract: Conclusions & Future Directions• Our synthesizability tool:• Creates multiple protected versions of a given non-natural amino acid • Considers SPPS specifical protection groups • Scores the synthesizability of each route • Facilitates the evaluation of retrosynthesis planning• Our tool can be used to:• Rank the synthetic feasibility of all the protection strategies for a given novel NNAA • In addition to other peptide optimization scoring functionsWe are conducting validation studies on the synthesis and characterization of some of the non-natural amino acids for the KEAP1-NEH2 model system. Scoring the Synthesizability of Any Novel Non-natural Amino Acid

Source: European Peptide Symposium (EPS)

DOI: 10.17952/37eps.2024.p2276

Authors: Gökçe Geylan, Mikhail Kabeshov, Samuel Genheden, Thierry Kogej, Ola Engkvist, Leonardo De Maria

Institutions: Chalmers University of Technology, AstraZeneca (Sweden), University of Gothenburg

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W4402813462

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